Prevalence of Human Papillomavirus Variants and Genetic Diversity in the L1 Gene and Long Control Region of HPV16, HPV31, and HPV58 Found in North-East Brazil

Table 5

HPV31 L1 sequence variations at the genome and protein level and the putative biological function affected.

Genome Position	Variation	AA changed	Protein position (relative to HPV16 L1 gene)	Number of isolates	Biological function
5926	A/G	—		1/4
5927	T/C	—		1/4
6025	A/G	T267A	FG loop	1/4	MHC Class-I/HC Class-II
6091	C/T	—		1/4
6335	G/A	—		1/4
6357	A/G	—		1/4
6374	C/T	—		1/4
6379	C/A	T274N	FG loop	1/4	B-cell/MHC Class-I
6593	T/G	—		1/4

(—) Synonymous variations with regard to the reference sequence J04353.1. T: threonine; N: asparagine; A: alanine.