Prevalence of Human Papillomavirus Variants and Genetic Diversity in the L1 Gene and Long Control Region of HPV16, HPV31, and HPV58 Found in North-East Brazil
Table 7
HPV58 L1 sequence variations at the genome and protein level and the putative biological function affected.
Genome position
Variation
AA changed
Number of isolates
Protein position relative to HPV16 L1 gene
Biological function
5593
C/T
—
2/8
5747
T/C
—
1/8
5789
T/C
—
1/8
5801
A/G
—
1/8
5819
A/G
—
1/8
5861
C/G
—
1/8
5939
G/A
—
1/8
5994
G/A
V144I
3/8
DE loop
B-cell/MHC Class-I
6014
A/C
L150F
5/8
DE loop
B-cell/MHC Class-II
6038
C/T
—
1/8
6039
A/G
—
1/8
6046
G/A
—
1/8
6051
C/A
—
1/8
6172
A/G
—
1/8
6206
G/A
—
1/8
6222
A/G
—
1/8
6405
G/A
—
4/8
6417
A/G
—
4/8
6435
T/C
—
4/8
6440
A/C
—
1/8
6441
A/C
—
1/8
6459
G/A
—
1/8
6459
G/T
—
1/8
6460
G/A
—
1/8
6497
T/G
—
1/8
6497
C/T
—
1/8
6540
A/G
I325M
6/8
-G1
MHC Class-I/MHC Class-II
6642
G/A
—
4/8
6689
C/A
T375N
2/8
HI loop
B-cell/MHC Class-I/MHC Class-II
6693
G/A
—
1/8
6698
G/A
—
1/8
6712
G/A
—
1/8
6799
A/G
I412V
3/8
H2
MHC Class-I/VLP formation
6823
G/A
D420N
2/8
H3
B-cell/MHC Class-I/MHC Class-II/VLP formation
6828
C/A
N422D
4/8
H3
B-cell/MHC Class-I/MHC Class-II/VLP formation
6829
A/G
—
3/8
(—) Synonymous variations with regard to the prototype reference D90400.1. T: threonine; N: asparagine; D: aspartic acid; V: valine; I: isoleucine; L: leucine; F: phenylalanine; M: methionine.
