Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

Table 1

List of genomes analyzed in this study. Genomic feature, statistics, accession numbers (chromosome + plasmid) and pangenomic data generated by analyzing 39 Helicobacter pylori strains. The number of predicted proteins, clusters, new genes (unique), and core and pan genome is estimated.

Organisms	Genomic features and statistics				Pan-genomics and comparative genomics
	Size (bp)	Proteins	Chromosome	Plasmid	%AT	New genes	New; families	Pan-genome	Core; genome
Helicobacter pylori 2017	1548238	1503	NC_017374.1		60.698	1503	1491	1491	1491
Helicobacter pylori 2018	1562832	1508	NC_017381.1		60.706	29	29	1520	1464
Helicobacter pylori 26 695	1667867	1579	NC_000915.1		61.124	207	189	1702	1323
Helicobacter pylori 35A	1566655	1500	NC_017360.1		61.132	106	103	1800	1291
Helicobacter pylori 51	1589954	1515	NC_017382.1		61.230	80	79	1871	1278
Helicobacter pylori 52	1568826	1509	NC_017354.1		61.059	63	62	1926	1273
Helicobacter pylori 83	1617426	1559	NC_017375.1		61.277	87	84	2004	1268
Helicobacter pylori 908	1549666	1511	NC_017357.1		60.701	24	24	2023	1264
Helicobacter pylori B38	1576758	1502	NC_012973.1		60.840	61	52	2065	1237
Helicobacter pylori B8 6296	1680029	1579	NC_014256.1	NC_014257.1	61.215	51	50	2097	1235
Helicobacter pylori Cuz20	1635449	1536	NC_017358.1		61.136	73	72	2153	1227
Helicobacter pylori ELS37	1669876	1564	NC_017063.1	NC_017064.1	61.123	57	55	2194	1224
Helicobacter pylori F16	1575399	1508	NC_017368.1		61.115	28	26	2205	1225
Helicobacter pylori F30	1579693	1498	NC_017365.1	NC_017369.1	61.197	19	19	2210	1225
Helicobacter pylori F32	1581461	1506	NC_017366.1	NC_017370.1	61.143	21	21	2218	1223
Helicobacter  pylori F57	1609006	1530	NC_017367.1		61.272	16	16	2226	1221
Helicobacter pylori G27	1663013	1577	NC_011333.1	NC_011334.1	61.130	51	51	2266	1221
Helicobacter pylori Gambia 9424	1712468	1589	NC_017371.1	NC_017364.1	60.876	28	28	2286	1220
Helicobacter pylori HPAG1	1605736	1508	NC_008086.1	NC_008087.1	60.933	32	32	2310	1220
Helicobacter pylori HUP-B14	1607584	1507	NC_017733.1	NC_017734.1	60.957	37	35	2339	1219
Helicobacter pylori India7	1675918	1572	NC_017372.1		61.102	33	32	2362	1217
Helicobacter pylori J99	1643831	1505	NC_000921.1		60.811	18	18	2373	1216
Helicobacter pylori Lithuania75	1640673	1555	NC_017362.1	NC_017363.1	61.134	42	42	2401	1212
Helicobacter pylori P12	1684038	1587	NC_011498.1	NC_011499.1	61.213	22	22	2411	1206
Helicobacter pylori PeCan18	1660685	1543	NC_017742.1		60.981	17	17	2415	1208
Helicobacter pylori PeCan4	1638269	1532	NC_014555.1	NC_014556.1	61.089	27	27	2435	1208
Helicobacter pylori Puno120	1637762	1532	NC_017378.1	NC_017377.1	61.095	26	26	2452	1206
Helicobacter pylori Puno135	1646139	1539	NC_017379.1		61.176	14	14	2463	1205
Helicobacter pylori SAfrica7	1679829	1573	NC_017361.1	NC_017373.1	61.575	48	47	2498	1206
Helicobacter pylori Sahul64	1644275	1579	ALWV01		61.240	32	30	2513	1205
Helicobacter pylori Sat464	1567570	1464	NC_017359.1	NC_017356.1	60.908	15	15	2521	1205
Helicobacter pylori Shi112	1663456	1561	NC_017741.1		61.227	10	10	2519	1205
Helicobacter pylori Shi169	1616909	1516	NC_017740.1		61.136	6	6	2521	1205
Helicobacter pylori Shi417	1665719	1545	NC_017739.1		61.229	14	14	2530	1204
Helicobacter pylori Shi470	1608548	1518	NC_010698.2		61.229	7	7	2530	1203
Helicobacter pylori SJM180	1658051	1524	NC_014560.1		61.100	15	15	2540	1203
Helicobacter pylori SNT49	1610830	1514	NC_017376.1	NC_017380.1	61.004	12	12	2540	1202
Helicobacter pylori v225d	1595604	1510	NC_017355.1	NC_017383.1	61.055	15	15	2549	1199
Helicobacter pylori XZ274	1656544	1701	NC_017926.1	NC_017919.1	61.427	89	89	2614	1193