Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

Table 2

Biological categorization of candidate essential gene families. The H. pylori EGFs analyzed by CELLO and PSORTb for prediction of surface proteins. This is followed by calculation of molecular weight of proteins by Expasy tool and Blast2go is used for functional annotation.

Protein	Localization	Mol. weight (Da)	EC number	Sequence; description
SeqID: /gene_family=“1495”	Cytoplasmic; Outer membrane	76937.16
SeqID: /gene_family=“1623”	Outer membrane; Inner membrane	81336.76	EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5	Copper-exporting ATPase
SeqID: /gene_family=“1487”	Extracellular; Outer membrane	51589.98	EC 3.4.21	Serine protease
SeqID: /gene_family=“1447”	Outer membrane; Cytoplasmic	24108.16
SeqID: /gene_family=“821”	Inner membrane; Outer membrane	26170.79
SeqID: /gene_family=“222”	Inner membrane; Cytoplasmic	61901.64		ABC transporter permease
SeqID: /gene_family=“197”	Inner membrane	32817.21	EC 2.5.1	Prenyltransferase
SeqID: /gene_family=“577”	Inner membrane	25149.00		Membrane protein
SeqID: /gene_family=“1486”	Inner membrane	62563.95		Insertase
SeqID: /gene_family=“948”	Inner membrane	52460.09		Lysine-specific permease
SeqID: /gene_family=“1028”	Cytoplasmic; Inner membrane	33346.74	EC 1.1.1.8	Glycerol-3-phosphate dehydrogenase
SeqID: /gene_family=“1439”	Inner membrane	46137.77		Potassium transporter
SeqID: /gene_family=“1480”	Inner membrane	53997.01		Sodium proline symporter
SeqID: /gene_family=“714”	Inner membrane	49579.70		Sodium: neurotransmitter symporter family protein
SeqID: /gene_family=“1238”	Inner membrane	115481.83		Cation efflux system protein
SeqID: /gene_family=“230”	Outer membrane; Extracellular	30259.72	EC 1.3.1.9	Enoyl-acp reductase
SeqID: /gene_family=“940”	Extracellular	33739.71
SeqID: /gene_family=“792”	Extracellular	39410.96
SeqID: /gene_family=“747”	Cytoplasmic; Outer membrane; Extracellular	32881.19		Domain protein
SeqID: /gene_family=“30”	Periplasmic	30271.1		50s ribosomal protein l2
SeqID: /gene_family=“1043”	Periplasmic; Cytoplasmic	15669.30
SeqID: /gene_family=“128”	Periplasmic; Cytoplasmic	37289.58	EC 3.5.1.49	Formamidases
SeqID: /gene_family=“428”	Periplasmic	40467.09	EC 1.1.1.1	NADP-dependent alcohol dehydrogenase
SeqID: /gene_family=“664”	Cytoplasmic; Periplasmic	26515.58	EC 3.6.1.3	Abc transporter ATP-binding protein
SeqID: /gene_family=“928”	Periplasmic	61103.25	EC 2.3.2.2	Gamma-glutamyltranspeptidase
SeqID: /gene_family=“1097”	Periplasmic	65613.27	EC 3.1.4.16	5-nucleotidase protein
SeqID: /gene_family=“88”	Cytoplasmic membrane	21533.23		Membrane protein
SeqID: /gene_family=“1595”	Cytoplasmic membrane	74214.44	EC 2.41.129	Penicillin-binding protein 1a
SeqID: /gene_family=“387”	Periplasmic	62296.56		Peptide ABC transporter substrate-binding protein