Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites

Table 1

Proteasome subunits composition in diferent species of eukaryotic cells.

Protein complex	Subunits	Systematic nomenclature	Miscellaneous nomenclature
			Human	Yeast	Trypanosomes
		α1	Iota	SCL1, YC7	Tbα1
		α2	C3	PRE8, Y7	Tbα2
		α3	C9	PRE9, Y13	Tbα3
	α Type	α4	C6	PRE6	Tbα4
		α5	zeta	PUP2, DOA5	Tcα5, TbPSA5
		α6	C2	PRE5	Tcpr29α6, Tbα6
		α7	C8	PRE10, YC1	Tbα7
	β Type	β1	Y, delta	PRE3	Tbβ1
20S		β2	Z	PUP1	Tbβ2
		β3	C10	PUP3	Tbβ3
		β4	C7	PRE1	Tbβ4
		β5	X, MB1, epsilon	PRE2, DOA3	Tbβ5
		β6	C5	PRE7	Tbβ6
		β7	N3, beta	PRE4	Tbβ7
		β1i	LMP2, RING12
		β3i	LMP10, MECL1
		β5i	LMP7, RING10
	ATPase	RPT1	57, MSS1	YTA3, CIM5	TcS7
		RPT2	54, P56	YTA5, mts2	TcS4
		RPT3	56, Tbp7, P48	YTA2	TcS6
		RPT4	S10b, p42	SUG2, CRL3, PLS1	TcS10b
		RPT5	S6′, Tbp1	YTA1	TcYTA-1
		RPT6	58, p45, Trip1	SUG1, CRL3, CIM3/let1	TcS8
		Rpn1	S2, p97	HRD2, NAS1/mts4	TcRpn1, TbRpn1
		Rpn2	S1, p112	SEN3	TbRpn2
		Rpn3	S3, p58	SUN2	TbRpn3
19S		Rpn5	p55	NA55	TbRpn5
		Rpn6	S9, p44.5	NAS4	TbRpn6
		Rpn7	S10a, P44		TbRpn7
	Non ATPase	Rpn8	S12, p40, MOV 34	NAS3	TbRpn8
		Rpn9	S11, p40.5	NAS7, mts1	TbRpn9
		Rpn10	S5a, MBP1	SUN1, MCB1, pus1	TbRpn10
		Rpn11	S13, Poh1	MPR1, pad1, mts5	TbRpn11
		Rpn12	S14, p31	NIN1/MTS3
		Rpn13	ADRM1	DAQ1
		Rpn15	DSS1, SHFM1	SEM1