Splicing Regulators and Their Roles in Cancer Biology and Therapy

Figure 1

Dysregulation of splicing factors activity in cancer cells. Alternative splicing can generate physiological relevant transcripts in nontumor cells. Alterations in the splicing machinery, such as overexpression or dysregulation of function in regulatory splicing factors, that is, SRPKs, CLKs, or SR proteins, promote angiogenesis, tissue invasion, metastasis, apoptosis evasion, or survival in cancer. These aspects of cancer biology are supported by isoforms that predominate in tumor cells [57, 61–69].