Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer

Table 1

Relation between CD133 and CD44 (cytoplasmic, membranous, and cytoplasmic/membranous positivity) markers with clinical pathological features in TNBC patients.

	CD133		value	CD44C		value	CD44M		value	CD44CM		value
	Negative	Positive		Low	High		Low	High		Low	High
Age
<40	11 (63,1%)	4 (36,9%)	0,806	15 (78,9%)	4 (21,1%)	0,783	18 (94,7%)	1 (5,3%)	0,440	19 (100%)	0 (0%)	0,051
>40 ≤ 60	49 (84,6%)	13 (15,4%)		42 (72,4%)	16 (27,6%)		52 (89,7%)	6 (10,3%)		54 (93,1%)	4 (6,9%)
>60	55 (75,7%)	13 (24,3%)		50 (80,6%)	15 (19,4%)		62 (95,4%)	3 (4,6%)		65 (100%)	0 (0%)
Missed data	1	0		1	0		1	0		1	0
Histotype
IDC	93 (76,9%)	28 (23,1%)	0,088	88 (75,2%)	29 (24,8%)	0,855	107 (91,5%)	10 (8,5%)		114 (97,4%)	3 (2,6%)	0,720
NIDC	23 (92%)	2 (8%)		20 (76,9%)	6 (23,1%)		26 (100%)	0 (0%)	0,122	25 (96,2%)	1 (3,8%)
Missed data	0	0		0	0		0	0		0	0
Size
≤2 cm	55 (79,7%)	14 (20,3%)	0,934	48 (75%)	16 (25%)	0,768	60 (93,8%)	4 (6,2%)	0,408	63 (98,4%)	1 (1,6%)	0,470
>2 ≤ 5	49 (79%)	13 (21%)		47 (73,4%)	17 (26,6%)		60 (93,8%)	4 (6,2%)		61 (95,3%)	3 (4,7%)
>5	9 (75%)	3 (25%)		10 (83,3%)	2 (16,7%)		10 (83,3%)	2 (16,7%)		12 (100%)	0 (0%)
Missed data	3	0		3	0		3	0		3	0
LNM
Negative	63 (80,5%)	19 (19,5%)	0,517	62 (77,5%)	18 (22,5%)	0,333	73 (91,3%)	7 (8,7%)	0,439	76 (95%)	4 (5%)	0,087
Positive	48 (90,6%)	11 (9,4%)		40 (70,2%)	17 (29,8%)		54 (94,7%)	3 (5,3%)		57 (100%)	0 (0%)
Missed data	5	0		6	0		6	0		6	0
Metastasis
Negative	89 (77,4%)	26 (25,6%)	0,235	90 (80,4%)	22 (19,8%)	0,011	102 (91%)	10 (9%)	0,085	108 (96,4%)	4 (3,6%)	0,286
Positive	27 (87%)	4 (13%)		18 (58,1%)	13 (41,9%)		31 (100%)	0 (0%)		31 (100%)	0 (42%)
Missed data	0	0		0	0		0	0		0	0
Grading
G1	2 (100%)	0 (0%)	0,223	1 (100%)	0 (0%)	0,844	1 (100%)	0 (0%)	0,463	1 (100%)	0 (0%)	0,751
G2	15 (93,7%)	1 (6,3%)		12 (75%)	4 (25%)		16 (100%)	0 (0%)		16 (100%)	0 (0%)
G3	96 (76,8%)	29 (23,2%)		91 (74,6%)	31 (25,4%)		112 (91,8%)	10 (8,2%)		118 (96,7%)	4 (3,3%)
Missed data	3	0		4	0		4	0		4	0
Ki67
≤20%	24 (85,7%)	4 (14,3%)	0,358	23 (92%)	3 (8%)	0,078	24 (92,3%)	2 (7,7%)	0,941	26 (100%)	0 (0%)	0,324
>20%	88 (77,9%)	25 (22,1%)		79 (71,8%)	31 (28,2%)		102 (92,7%)	8 (7,3%)		106 (96,4%)	4 (3,6%)
Missed data	4	1		6	1		6	0		7	0

IDC = infiltrant ductal carcinoma; NIDC = noninfiltrant ductal carcinoma; LNM = lymph node metastasis.