BioMed Research International / 2015 / Article / Tab 1 / Review Article
Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data Table 1 Main characteristics and results of the eligible studies for evaluation of overall survival.
Study (author/year) Country Number of patients Age (y) Median (range) ALP cut-off (IU/L) Enneking stage HR (95% CI) Follow-up (m) Median (range)
Aparicio et al., 1999 [25 ] Spain 33 17 (12–42) 115 II 1.26 (0.42–3.74) 96 (60–156) Foukas et al., 2002 [26 ] UK 45 18 (6–48) NA IIB 3.44 (1.52–7.79) 68 (28–88) Ford et al., 2004 [27 ] UK 350 NS (<40) NA II 1.66 (1.09–2.51) NA Bramer et al., 2005 [28 ] UK 89 NA NA II 1.49 (0.72–3.06) NA Mialou et al., 2005 [29 ] France 60 13.5 (2–19) 500 IIIB 2.2 (1.2–4.1) NA Yalçın et al., 2008 [30 ] Turkey 55 13 (7–17) NA II-III 1.1 (0.5–2.41) NA Chou et al., 2009 [31 ] USA 91 NA NA III 3.16 (1.77–5.36) 89 (1–141) Kim et al., 2009 [32 ] Korea 67 15.7 (3.8–644) NA II 1.37 (0.54–3.45) 59.9 Wu et al., 2009 [33 ] Taiwan ROC 91 20.2 (5–84) A† II-III 2.52 (1.32–4.75) 58.2 (2–233) Yao et al., 2009 [34 ] China 57 16 (6–70) 136 II-III 3.45 (1.4–8.46) 32.5 (10–52) Hagleitner et al., 2011 [35 ] Netherlands 94 17.8 (4.5–39.5) NA II-III 1.66 (0.88–3.11) 67.2 (28.8–360) Ferrari et al., 2012 [36 ] Italy 209 14 (4–39) A II 1.69 (0.98–2.9) 76 (31–115) Han et al., 2012 [37 ] China 177 23.2 (5–57) A II 1.80 (1.28–2.51) 87 (8–144) Durnali et al., 2013 [38 ] Turkey 211 20 (13–74) A II-III 1.75 (1.23–2.5) 30.5 (0.5–213) Min et al., 2013 [39 ] China 333 19 (5–78) NA II-III 1.73 (1.28–2.33) NA (1–100) Hung et al., 2015 [40 ] Taiwan ROC 69 13.5 (3.8–17.7) 150 II-III 3.08 (1.05–9.08) 51.6 (18–111.6) Berner et al., 2015 [41 ] Norway 301 NA A II-III 1.64 (1.22–2.19) NA
NA: not available, A: available (see the footnotes for details), HR: hazard ratio, CI: confidence interval, y: year(s), and m: month(s). : 2 times of upper limit normal level. : ALP cut-off: 2–10 y 100–350 IU/L; 10–13 y female 110–400 IU/L; 13–15 y male 125–500 IU/L; 20–50 y 25–100 IU/L; other childhood age 73–300 IU/L. §: ALP cut-off: >18 y 150 IU/L; <18 y 110 IU/L. Δ: ALP cut-off: 0–17 y 400 IU/L; >17 y 105 IU/L.