Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data

Table 3

Main characteristics and results of the eligible studies for evaluation of presence of metastasis at diagnosis.

Study; (author/year)	Country	Number of patients	Age (y)	ALP cut-off (IU/L)	Enneking stage	RR (95% CI)
Bacci et al., 1993 [43]	Italy	549	NA	A	II-III	5.53 (2.85–10.74)
Wu et al., 2009 [33]	Taiwan ROC	91	20.2 (5–84)	A	II-III	16.5 (1.05–260.27)
Hung et al., 2015 [40]	Taiwan ROC	76	13.5 (3.8–17.7)	150	II-III	18.6 (1.17–294.97)

NA: not available, A: available (see the footnotes for details), RR: relative risk, and CI: confidence interval.
: ALP cut-off: 2–10 y 350 IU/L; 10–13 y female 400 IU/L; 13–15 y male 500 IU/L; 20–50 y 100 IU/L; other childhood age 300 IU/L.