Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data

Table 5

A summary of HRs for the overall and subgroup analyses of SALP and OS of osteosarcoma patients.

	Number of studies	Patients number	HR (95% CI)	Heterogeneity
				Chi-squared		value
Overall	17	2272	1.82 (1.61–2.06)	13.68	0%	0.622
Age
Preadult and adult	14	2088	1.82 (1.60–2.06)	10.83	0%	0.625
Preadult only	3	184	1.87 (1.20–2.91)	2.84	2.96%	0.242
Enneking stage
II	7	910	1.75 (1.42–2.15)	3.53	0%	0.740
II-III	8	1211	1.77 (1.61–2.06)	6.02	0%	0.538
III	2	151	2.67 (1.75–4.06)	0.71	0%	0.400
Sample size
<100	11	751	2.13 (1.70–2.66)	10.94	8.6%	0.362
>100	6	1521	1.71 (1.48–1.98)	0.20	0%	0.999
Geographic region
Asia	6	734	1.89 (1.55–2.31)	4.16	0%	0.527
Non-Asia	11	1538	1.78 (1.53–2.07)	9.29	0%	0.505

HR: hazard ratio, OS: overall survival, and CI: confidence interval.