Identification and Analysis of the SET-Domain Family in Silkworm, Bombyx mori

Figure 1

SET-domain sequence alignment analysis. The figure shows invariant residues in binding to the catalytic substrate AdoMet (S-adenosyl-L-methionine) the target lysine, catalytic site, the most conserved NHSC motif, F/Y switch controlling whether the product is a mono-, di-, or trimethylated histone, and the pseudoknot structure formed by two conserved SET motifs to form an active site in a location immediately next to the peptide-binding cleft. Sc: Saccharomyces cerevisiae; Hs: Homo sapiens; Dm: Drosophila melanogaster.