Research Article

Identification and Analysis of the SET-Domain Family in Silkworm, Bombyx mori

Table 1

SET-domain genes identified from the SilkDB.

SubfamilyGene nameGene holonameName in SilkDBConserved domain
(addition to SET)
ORF length (bp)Chromosome numberScaffoldESTsProbe-valueMethylase activity in other species

SUV39BmG9a-like/Ehmt2Euchromatic histone-lysine N-methyltransferase 2BGIBMGA007949Ankyrin repeats, Pre-SET, and ALAD416115nscaf28887sw00703, sw17591,
sw15556, and sw17724
H3K9, H3K27
BmSetdb1SET-domain, bifurcated 1BGIBMGA011407Tudor, MBD, Pre-SET, and Post-SET289523 Nscaf3026Nosw21024, sw184430.0H3K9
BmSu(var)3-9Suppressor of variegation 3-9BGIBMGA011500, BGIBMGA011499CHROMO, Pre-SET, and Post-SET178223 Nscaf302712sw11427, sw044710.0H3K9

SET1BmMllMyeloid/lymphoid or mixed-lineage leukemiaBGIBMGA010221PHD, FYRN, FYRC, and Post-SET126577nscaf29862sw12266, sw149740.0H3K4
BmSet1SET-domain-containing 1BGIBMGA012978Post-SET408016 Nscaf3058Nosw14237, sw14238,
sw16463, and sw04801
0.0H3K4
BmTrrTrithorax-relatedBGIBMGA002503, BGIBMGA002502PHD, FYRN, and Post-SET9nscaf25114sw05846, sw04238,
sw06661, and sw10095
0.0 
H3K4
BmMll5Myeloid/lymphoid or mixed-lineage leukemia 5BGIBMGA004310PHD20nscaf2789Nosw00989, sw16148H3K4
BmSET2SET-domain-containing 2BGIBMGA003106AWS, Post-SET36334nscaf2589Nosw11671, sw11672H3K36

SET2BmNsd1Nuclear receptor binding SET-domain protein 1BGIBMGA002246PWWP, PHD, AWS, and Post-SET660026nscaf23303sw11742H3K36, H4K20
BmAsh1Absent, small, or homeotic discs 1BGIBMGA001497AWS, Post-SET, BROMO, PHD, and BAH875421nscaf21362sw115620.0H3K4, H3K9, and H4K20

SUV4-20BmSu(var)4-20Suppressor of variegation 4-20 BGIBMGA000919209413 Nscaf18984sw13536H4K20

EZBmE(z)Enhancer of zesteBGIBMGA014476SANT, CxCScaffold7076sw15702, sw162170.0H3K27

SMYDBGIBMGA014048zf-MYND1782 Nscaf31151sw10812
BGIBMGA007907188115nscaf2888Nosw11109
BGIBMGA00207622321nscaf22101sw19609
BGIBMGA011073115523 Nscaf3015Nosw20741
BGIBMGA00210910711nscaf2210Nosw18112, sw02496
BGIBMGA008839zf-MYND3nscaf2927Nosw17374, sw17507
BGIBMGA008939zf-MYND3nscaf2930Nosw08614
BGIBMGA0088383nscaf2927Nosw21409
BGIBMGA0089233nscaf2930Nosw21256
BGIBMGA0031394nscaf2589Nosw05603

OthersBmSet8/PR-set7SET-domain-containing (lysine methyltransferase) 8BGIBMGA01285391216 Nscaf30581H4K20
BmSetmarSET-domain and mariner transposase fusion geneBGIBMGA00755781015nscaf28872