CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes

Figure 1

Effect of specific CK2 inhibitors (heparin, TBB, and DRB) on the proliferationof L. braziliensis avirulent (a) and virulent (b) samples. The assay was performed as described in Section 2. The values are presented as the mean of 3 independent experiments conducted in triplicate. In (a), () heparin and DRB significantly inhibited proliferation after 72 hours. In (b), () heparin significantly inhibited proliferation after 48 hours, and TBB and DRB significantly inhibited proliferation after 72 hours (one-way ANOVA and Tukey’s post hoc test) (◆ Control; ■ 1 mM Casein; ▲ 1 µM TBB; — 10 µg/mL Heparin; ● 6 µM DRB).

(a)

(b)