Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAs/isomiRs Levels

Figure 4

IsomiR expression patterns across different samples. IsomiR is presented here based on the location on chromosome (the detailed location distributions can be found in Tables , , and ). The percentage shows the relative expression levels in the miRNA locus. The mean and standard deviation are presented in the figure. BRCA-NT or UCEC-NT shows normal samples that match tumor samples. (a) IsomiR expression patterns of let-7a-5p across the five kinds of samples. Similar distributions can be found across the different samples. The right bar chart indicates distribution of the mean percentage and standard deviation of the five kinds of samples. ((b)-(c)) IsomiR expression patterns of homologous miR-30a and miR-30e. Both of them can generate two kinds of abundant products (miR-#-5p and miR-#-3p). The two arms may show various isomiR expression patterns, but homologous miRNAs are likely to show similar expression patterns. (d) IsomiR expression patterns of miR-10b and miR-21.

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