Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced β-Cell Damage and Streptozotocin-Induced Diabetes

Table 1

Effect of LD extract on body weight, liver weight, kidney weight, diet intake, water intake, and urine volume in STZ-induced diabetic rats.

Group	Body weight (g)		Liver weight	Kidney weight	Diet intake	Water intake	Urine volume
	Initial	Final	(g/100 g BW)	(g/100 g BW)	(g/day)	(mL/day)	(mL/day)
Normal	238 ± 2	350 ± 7^c	2.63 ± 0.07^a	0.64 ± 0.01^a	27.6 ± 0.2^a	57.1 ± 2.0^a	25.3 ± 1.6^a
Control	214 ± 2	203 ± 6^a	3.72 ± 0.16^b	1.06 ± 0.04^b	44.6 ± 1.2^c	289.3 ± 13.1^d	149.7 ± 11.0^c
LD	215 ± 2	228 ± 3^b	3.86 ± 0.09^b	1.04 ± 0.03^b	39.3 ± 0.9^ab	210.3 ± 2.62^b	127.5 ± 14.2^b
TLB	210 ± 3	234 ± 2^b	3.33 ± 0.58^b	1.06 ± 0.06^b	33.2 ± 4.9^bc	235.7 ± 1.49^c	86.0 ± 15.6^b

Values are means ± SE for each group of eight animals. Values with different letters are significantly different ( < 0.05, Duncan’s multiple comparison tests). LD (L. davurica) and TLB (tolbutamide) were administered at a dose of 250 mg/kg body weight for 5 weeks.