Focal virus-mediated VEGF gene transferred in the brain of Alk1 mice: cerebral microvascular dysplasia, less severe compared to Eng mice, promoted by increased cerebral perfusion
Conditional knockout of Alk1 by globally expressed Cre in adult mice: AV fistula formations and spontaneous hemorrhage in other organs, not remarkable in the brain
To investigate the pathogenic and hemorrhagic mechanisms of AVMs
Conditional knockout of Eng by globally expressed Cre in adult mice: no remarkable effects on brain vasculature, angiogenesis and cerebrovascular lesions mimicking human AVM nidus developed with focal virus-mediated VEGF gene transferred
Conditional knockout of Alk1 specifically in endothelial cells in adult mice: AVM formation and spontaneous hemorrhage in other organs and brain areas with previously focal virus-mediated VEGF gene transferred
To evaluated the role of endothelia in the pathogenesis of AVMs
Conditional knockout of Eng specifically in endothelial cells in postnatal mice: endothelial proliferation and AVM formation in neonatal retina, local venomegaly in adult skin induced by angiogenic stimulation