Research Article
Early Fluid Resuscitation and High Volume Hemofiltration Decrease Septic Shock Progression in Swine
Table 1
Hemodynamic parameters observed during animal model building.
| | Variable | Baseline | 30 min | 40 min | 50 min | 60 min | |
| | MAP (mmHg) | 113 ± 4.7 | 98 ± 5.9 | 87 ± 5.7 | 80 ± 6.2 | 78 ± 2.5 | <0.005 | | HR (bpm) | 109 ± 4.4 | 130 ± 3.7 | 136 ± 4.7 | 144 ± 6.5 | 149 ± 5.4 | <0.005 | | CO (L/min) | 4.1 ± 0.4 | 5.6 ± 0.8 | 4.0 ± 0.3 | 3.4 ± 0.3 | 2.9 ± 0.3 | <0.005 | | SVV (%) | 9.1 ± 1.3 | 19.7 ± 1.7 | 24.2 ± 0.7 | 26.2 ± 0.6 | 26.8 ± 1.3 | <0.005 | | dPmax (mmHg/s) | 763 ± 98.9 | 467 ± 38.4 | 334 ± 29.0 | 344 ± 29.8 | 311 ± 33.2 | <0.005 | | BT (°C) | 38.8 ± 0.4 | 39.2 ± 0.4 | 39.4 ± 0.2 | 39.7 ± 0.3 | 40.1 ± 0.5 | <0.005 | | SVR (dyn·s·cm−5) | 1931 ± 274.5 | 2749 ± 485.6 | 2289 ± 400.5 | 1564 ± 176.6 | 1127 ± 104.3 | <0.005 | | CVP (mmHg) | 6.1 ± 2.1 | — | — | — | 3.9 ± 1.9 | <0.005 |
|
|
MAP: mean arterial pressure; HR: heart rate; CO: cardiac output; SVV: stroke volume variability; dPmax: left ventricular contractility index; BT: blood temperature; SVR: systemic vascular resistance; CVP: central venous pressure.
and versus baseline.
|
