Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma
Table 1
Clinicopathologic sample characteristics and MT1-MMP expression.
Number of patients
79
m/f
45/34
Age (yrs, median/range/IQR)
75/25–92/15
Tumor localization (right/left colon/unknown)
27/48/4
MT1-MMP expression
MT1-MMP−
MT1-MMP+
P
Histopathological grading ()
Low-grade
15
16
1.0
High-grade
21
24
UICC stage ()
I
11
16
0.8934
II
10
7
III
11
14
IV
4
5
T stage ()
T1/2
12
16
0.633
T3/4
24
23
N stage ()
N0
20
21
1.0
N1/2
14
16
KRAS mutation status ()
KRASwt
24
25
0.812
KRASmut1
12
15
BRAF mutation status ()
BRAFwt
32
35
1.0
BRAFmut2
4
5
MMR protein expression ()
MMR proteins expressed
32
28
0.471
Loss of MMR protein expression3
3
5
Presence of lymphovascular invasion ()
L0V0
14
21
0.336
L1/V1
15
13
L1V1
8
5
Tumor cell budding ()
Low-grade
26
31
0.609
High-grade
10
9
Growth pattern ()
Expanding
24
23
0.641
infiltrating
13
17
Tumor-infiltrating lymphocytes (TILs; )
Absent
24
25
1.0
Present
13
15
1KRAS G12D, G12V, G12C, G12S, and G12R; G13D; Q61K; Q61L; 2BRAF V600E; 3MLH-1, MSH-2, MSH-6, and PMS-2; 4Chi-Square test for trend.
