Research Article
CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis
Table 1
Serum cytokine levels in MS cases.
| Analyte | MS (ng/mL) | Control (ng/mL) |
| IL-1α | 6.6 ± 0.8 | 5.3 ± 2.2 | IL1b | 8.8 ± 0.9 | 6.6 ± 0.4 | IL-1ra | 23 ± 7.3 | 38 ± 17.2 | IL-2Ra | 320.3 ± 51.9 | 36.3 ± 4.1 | < 0.04 | | IL-2 | 56.23 ± 32 | 78 ± 27 | IL-3 | 82.0 ± 12.9 | 67.2 ± 13.4 | IL4 | 87.8 ± 15.4 | 63.0 ± 18.6 | IL-5 | 24.12 ± 17 | 33 ± 23 | IL-7 | 5.2 ± 0.3 | 6.2 ± 0.8 | IL-8 | 4.7 ± 0.5 | 6.6 ± 1.6 | IL-9 | 9.7 ± 1.7 | 7.3 ± 1.4 | IL10 | 73.6 ± 6.2 | 68.5 ± 10.2 | IL-12p40 | 4005.7 ± 327.1 | 86.0 ± 6.1 | < 0.00015 | | IL-12(p70) | 90.2 ± 17.9 | 84.1 ± 8.6 | IL-13 | 2.7 ± 0.3 | 2.1 ± 0.2 | IL-15 | 85.0 ± 3.4 | 68.6 ± 4.6 | IL-16 | 119.7 ± 33.9 | 241.1 ± 67.9 | IL17A | 103.79 ± 6.5 | 44.74 ± 6.3 | = 0.001 | | IL17F | 115.2 ± 8.3 | 44.7 ± 6.3 | IL-18 | 118.3 ± 12.0 | 101.9 ± 24.3 | IL21 | 184.3 ± 6.5 | 162.005 ± 16.1 | IL22 | 163.5 ± 7.7 | 149.358 ± 18.7 | IL23 | 481.4 ± 29.8 | 62.1517 ± 8.9 | < 0.000003 | | IL25 | 36.8 ± 1.9 | 32.4 ± 1.7 | IL31 | 230.5 ± 14.2 | 195.055 ± 29.8 | IL33 | 1050.4 ± 291.0 | 683.6 ± 158.2 | CCL2 | 915.9 ± 46.9 | 145.6 ± 23.0 | = 0.0000001 | | CCL3 | 73.8 ± 7.1 | 35.7 ± 4.1 | < 0.05 | | CCL4 | 64.2 ± 8.9 | 47.5 ± 13.2 | CCL5 | 8743.6 ± 2219.2 | 2589.5 ± 248.3 | CCL7 | 337.4 ± 55.2 | 119.8 ± 6.3 | CCL11 | 220.3 ± 25.0 | 113.5 ± 28.8 | CCL27 | 4674.9 ± 643.3 | 854.6 ± 51.0 | < 0.05 | | CXCL1 | 342.9 ± 46.2 | 135.6 ± 40.6 | CXCL9 | 2307.1 ± 338.7 | 2461.8 ± 301.6 | CXCL10 | 1804.3 ± 264.6 | 732.2 ± 111.5 | CXCL12 | 2575.6 ± 355.1 | 2582.4 ± 166.5 | IFN-α2 | 59.8 ± 6.7 | 33.5 ± 8.0 | INFγ | 74.1 ± 4.1 | 77.3 ± 8.9 | FGF basic | 34 ± 24 | 56 ± 26 | G-CSF | 26.3 ± 2.9 | 19.7 ± 4.3 | GM-CSF | 45 ± 21 | 76 ± 34 | HGF | 1206.7 ± 164.1 | 931.7 ± 287.7 | LIF | 44.0 ± 7.9 | 29.2 ± 14.5 | M-CSF | 430.2 ± 41.7 | 37.3 ± 7.0 | = 0.002 | | MIF | 401.1 ± 32.9 | 148.6 ± 38.9 | = 0.01 | | b-NGF | 6.6 ± 0.4 | 6.7 ± 0.8 | PDGF-bb | 1256 ± 235 | 1462 ± 562 | sCD40L | 3592.9 ± 620.7 | 2756.0 ± 1007.3 | SCF | 230.5 ± 25.8 | 142.7 ± 18.9 | SCGF-b | 51782.6 ± 8900.2 | 46927.3 ± 7531.6 | TNFα | 39.8 ± 3.5 | 55.0 ± 5.3 | TNF-β | 10.4 ± 1.4 | 7.0 ± 1.5 | TRAIL | 252.3 ± 41.7 | 46.2 ± 10.0 | VEGF | 114.6 ± 12 | 74.4 ± 10.4 |
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