Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy

Figure 1

mdr1 mRNA levels in the hippocampus and entorhinal cortex of rats with spontaneous seizures. Data are the means ± SE () of the optical density values of gel bands representing the PCR amplification products of mdr1 mRNA normalized to the corresponding β-actin band used in each sample as an internal standard. Values in spontaneously epileptic rats (SE) are expressed as a percentage of the control levels (sham-stimulated rats (Sham)). HP, stimulated hippocampus (1.8-fold increase); EC, contralateral entorhinal cortex (5.5-fold increase). versus sham according to a Mann-Whitney test.