MicroRNA181a Is Overexpressed in T-Cell Leukemia/Lymphoma and Related to Chemoresistance

Table 3

Inhibition miR181a expression sensitized T-leukemia/lymphoma cells to chemotherapeutic agents.

Agents

IC50

value

IC50

value

IC50

value

IC50

value

Jurkat control

Jurkat antagomir

Doxorubicin-resistant Jurkat control

Doxorubicin-resistant Jurkat antagomir

H9; control

H9; antagomir

Doxorubicin-resistant H9 control

Doxorubicin-resistant H9; antagomir

Cisplatin (uM)

6.6 ± 0.2

5.1 ± 0.1

0.0014

9.0 ± 0.4

7.0 ± 0.4

0.0215

5.7 ± 0.3

4.4 ± 0.2

0.0264

8.5 ± 0.5

6.0 ± 0.5

0.0191

Cyclophosphamide (mM)

3.3 ± 0.2

1.6 ± 0.2

0.0018

4.8 ± 0.2

3.6 ± 0.2

0.0214

2.4 ± 0.2

0.9 ± 0.1

0.0019

3.9 ± 0.3

2.5 ± 0.2

0.0134