A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats

Figure 2

WM130 and M19 inhibited the proliferation of HSC-T6 cells in vitro. (a) HSC-T6 cells were treated for 24 h with a series of different compounds at concentration of 0.1 mg/mL, and the cell viability was measured by MTT assay. (b) The effect of a series of different concentrations of WM130 or M19 was tested on cell viability of HSC-T6 cells. The inhibition rates were calculated by [inhibition rate = (1 − OD value of treatment group)/OD value of control group]. , versus control group; ^#, ^## versus M19 group.

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