A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats

Figure 7

WM130 inhibits DMN-induced rat liver fibrosis. The model of liver fibrosis was induced by intraperitoneal injection with 1% DMN. Then rats were treated with M19 or WM130 by gavage. (a) The contents of the collagen fiber in liver tissue of DMN-induced rat were detected by Van Gieson’s staining. The immunohistochemical staining was used to observe α-SMA, TGF-β1, p-AKT, and p-ERK positive areas in liver tissues of DMN-injured rats (at 200x magnification). (b) Sera were prepared from rat blood and used to determine the contents of ALT, AST, and Collagen I. , versus normal Control; ^#, ^### versus model Control.

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