Network Comparison of Inflammation in Colorectal Cancer and Alzheimer’s Disease

Figure 1

IPA functional enrichment of the CRC and the AD datasets. (a) Top 5 functional categories from “Diseases and Functions” ontology for the datasets are represented. The -axis represents the minus logarithms of the values. The higher the value on the -axis is, the more statistically significant it becomes. The -axis represents the functional categories. (b) The common genes inversely expressed between the two diseases are indicated by white ovals (see details in Section 2). In the Venn diagrams, “GSE12685 (AD) Dn” is the downregulated gene set in AD patients versus controls. “GSE12685 (AD) Up” is the upregulated gene set in AD patients versus controls. The notation is similar to the GSE1297 (AD) dataset and the GSE4107 (CRC) dataset.

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