Network Comparison of Inflammation in Colorectal Cancer and Alzheimer’s Disease

Table 2

KEGG pathways associated with the 16 oppositely expressed common genes (in Table 1) in the AD and the CRC networks. From the AD and the CRC networks, pathway information of the 16 genes was obtained. The 16 genes were inversely expressed in the pathways between the AD and the CRC networks.

Gene symbols	Pathways	CRC (GSE4107)	AD (GSE12685)	AD (GSE1297)
PTPN6	hsa04662_B_cell_receptor_signaling_pathway; hsa04630_Jak-STAT_signaling_pathway; hsa05140_Leishmaniasis	Up	Down	Down
IRAK3	hsa04722_Neurotrophin_signaling_pathway
FLT3	hsa05221_Acute_myeloid_leukemia
DDIT3	hsa04010_MAPK_signaling_pathway
FAS	hsa04115_p53_signaling_pathway; hsa04650_Natural_killer_cell_mediated_cytotoxicity
IRF3	hsa04622_RIG-I-like_receptor_signaling_pathway; hsa04623_Cytosolic_DNA-sensing_pathway
CCR6	hsa04060_Cytokine-cytokine_receptor_interaction; hsa04062_Chemokine_signaling_pathway
CD28	hsa04660_T_cell_receptor_signaling_pathway; hsa05416_Viral_myocarditis
FCER1G	hsa04650_Natural_killer_cell_mediated_cytotoxicity
NGFR	hsa04722_Neurotrophin_signaling_pathway
FN1	hsa04512_ECM-receptor_interaction
BAD	hsa04510_Focal_adhesion; hsa05223_Non-small_cell_lung_cancer; hsa05210_Colorectal_cancer	Down	Up	Up
CD36	hsa03320_PPAR_signaling_pathway; hsa04512_ECM-receptor_interaction
PPARD	hsa05221_Acute_myeloid_leukemia; hsa04310_Wnt_signaling_pathway
ABL1	hsa04012_ErbB_signaling_pathway; hsa04722_Neurotrophin_signaling_pathway
EGFR	hsa05214_Glioma; hsa04012_ErbB_signaling_pathway