Research Article
Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis
Table 5
Effect of icodextrin on lipid profiles (in subgroups of duration).
| Factor | Duration | Number of studies | Heterogeneity test | Weighted mean difference | | | value | Model of meta | Mean | [95% CI] | value |
| Total cholesterol (mmol/L) | <6 month | 6 | 9.49 | 47.30% | 0.091 | F | | | 0.096 | ≥6 month | 4 | 8.50 | 43.40% | 0.112 | F | | | <0.001 |
| Triglycerides (mmol/L) | <6 month | 5 | 26.45 | 84.90% | <0.001 | R | | | 0.096 | ≥6 month | 3 | 4.32 | 33.6% | 0.213 | F | | | 0.004 |
| HDL-C (mmol/L) | <6 month | 4 | 1.19 | <0.01% | 0.754 | F | | | 0.760 | ≥6 month | 2 | 0.76 | <0.01% | 0.383 | F | | | 0.469 |
| LDL-C (mmol/L) | <6 month | 4 | 4.71 | 36.3% | 0.194 | F | | | 0.435 | ≥6 month | 2 | <0.01 | <0.01% | 0.982 | F | | | 0.495 |
| VLDL-C (mmol/L) | <6 month | 4 | 0.09 | <0.01% | 0.761 | F | | | 0.527 |
| Free fatty acid (mol/l) | <6 month | 2 | 1.13 | 11.50% | 0.288 | F | | | 0.009 |
|
|
Note: the value was less than 0.05, and the WMD was considered statistically significant. Model of meta: F: Fixed, R: Random.
|