Animal Models and “Omics” Technologies for Identification of Novel Biomarkers and Drug Targets to Prevent Heart Failure

Figure 4

Spatial distribution of ezrin during adaptation and HF. (a) Longitudinal sections of the mouse myocardium 1 month after transaortic constriction (TAC). In sham operated animals ezrin shows a regular appearance at the intercalated disc, which is disturbed to a variable degree in mice after TAC (yellow circles). In the fluorescence micrographs cardiomyocytes show different degrees of ezrin translocation in cardiomyocytes (white arrows (TAC1) and oval circles (TAC2)). These animals recover after the release of constriction. (b) Fluorescence micrographs demonstrate massive lateral accumulation of ezrin in patients with end-stage HF. This pattern of moesin and radixin labeling corresponds with that previously described [14].

(a)

(b)