Assessing Apoptosis Gene Expression Profiling with a PCR Array in the Hippocampus of Ts65Dn Mice

Table 1

Differential apoptotic gene expressions in the hippocampus of Ts65Dn mice.

Gene symbol	Description of genes	Chromosome		Ts65Dn/control group
		Human	Mouse	Fold changes	value
API5	Apoptosis inhibitor 5	11	2	−11.55	0.00
AIFM1	Apoptosis-inducing factor, mitochondrion-associated, 1	X	X	−5.94	0.00
NFB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	4	3	3.11	0.02
Bcl-2	B-cell CLL/lymphoma 2	18	1	2.75	0.07
Ntrk1	Neurotrophic tyrosine kinase, receptor, type 1	1	3	2.59	0.09
Tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1A	12	6	2.52	0.1
Ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1	6	13	2.52	0.1
Rela	V-rel avian reticuloendotheliosis viral oncogene homolog A	11	19	2.52	0.1
Map3k14	Mitogen-activated protein kinase kinase kinase 14	17	11	2.52	0.1
Irak1	Interleukin-1 receptor-associated kinase 1	X	X	2.52	0.1
Il1a	Interleukin-1, alpha	2	2	2.52	0.1
Il10	Interleukin 10	1	1	2.52	0.1
Ikbkg	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	X	X	2.52	0.1
Ikbkb	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	8	8	2.52	0.1
Igf1r	Insulin-like growth factor 1 receptor	15	7	2.52	0.1
Fadd	Fas (TNFRSF6)-associated via death domain	11	7	2.52	0.1
Dffa	DNA fragmentation factor, 45 kDa, alpha polypeptide	1	4	2.52	0.1
Dapk1	Death-associated protein kinase 1	9	13	2.52	0.1
Cideb	Cell death-inducing DFFA-like effector b	14	14	2.52	0.1
Cidea	Cell death-inducing DFFA-like effector a	18	18	2.52	0.1
Cdc2a	Cyclin-dependent kinase A-1		10	2.52	0.1
Cd70	CD70 molecule	19	17	2.52	0.1
Casp-9	Caspase-9	1	4	2.52	0.1
Casp-8	Caspase-8	2	1	2.52	0.1
Casp-7	Caspase-7	10	19	2.52	0.1
Casp-6	Caspase-6	4	3	2.52	0.1
Casp-3	Caspase-3	4	8	2.52	0.1
Birc2	Baculoviral IAP repeat containing 2	11	9	2.52	0.1
Apaf1	Apoptotic protease-activating factor 1	12	10	2.52	0.1
Akt2	V-akt murine thymoma viral oncogene homolog 2	19	7	2.52	0.1
Akt3	V-akt murine thymoma viral oncogene homolog 3	1	1	3.3	0.13
Il1b	Interleukin-1, beta	2	2	6.75	0.14
Myd88	Myeloid differentiation primary response gene 88	3	9	3.54	0.15
Birc3	Baculoviral IAP repeat containing 3	11	9	3.63	0.15
Mapk3	Mitogen-activated protein kinase 3	16	7	3.21	0.17
Mapk1	Mitogen-activated protein kinase 1	22	16	6.59	0.29
Bid	BH3 interacting domain death agonist	22	6	−2.03	0.3
Fas	Fas cell surface death receptor	10	19	3.23	0.43
Casp-4	Caspase-4	11	9	1.7	0.48
Akt1	V-akt murine thymoma viral oncogene homolog 1	14	12	3.44	0.49
TNF	Tumor necrosis factor	6	17	2.01	0.5
Nfbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	14	12	2	0.56
Cd40lg	CD40 ligand	X	X	1.64	0.61
Pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2	19	8	−1.64	0.72
Casp-2	Caspase-2	7	6	−1.66	0.72
Tnfrsf10b	Tumor necrosis factor receptor superfamily, member 10b	8	14	1.49	0.75
Ppp3cc	Protein phosphatase 3, catalytic subunit, gamma isozyme	8	14	1.58	0.8
Xiap	X-linked inhibitor of apoptosis	X	X	−1.05	0.85
Ppp3r1	Protein phosphatase 3, regulatory subunit B, alpha	2	11	1.22	0.89
Bad	Bcl-2-associated agonist of cell death	11	19	1.15	0.9
Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	3	3	1.21	0.93
Endog	Endonuclease G	9	2	1.05	0.96
Pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	7	12	−1.01	0.99

Note: .