Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKL/OPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients

Figure 4

Effect of T-614 and MTX on IL-6-induced MMP-3, IL-17, and RORc mRNA expression in RASFs. RASFs were stimulated with IL-6/sIL-6R, T-614, or MTX for 72 h. The effect of T-614 and MTX on IL-6-induced IL-17 (a), RORc (b), and MMP-3 (c) mRNA expression in RASFs was tested by real-time quantitative PCR analysis. The data shown are the mean ± SD for three independent experiments, each in triplicate. ^∗∗∗, ^∗∗, and ^∗.

(a)

(b)

(c)