Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats
Table 2
Antidiabetic effects of oral administration of PSC aqueous extract on FBG, body weight, and urine sugar in diabetic rats (mean ± SD).
Experimental animals
Treatment
Pretreatment level
Posttreatment level
0 days
7 days
14 days
21 days
FBG (mmol/L)
Normal (control)
Distilled water
5.5 ± 0.2
5.7 ± 0.2
5.4 ± 0.1
5.5 ± 0.2
Diabetic (control)
Distilled water
10.2 ± 0.3
10.4 ± 0.2
10.2 ± 0.3
10.9 ± 0.4
Diabetic (treated)
Metformin (150 mg/kg)
10.4 ± 0.2
9.6 ± 0.1
8.9 ± 0.3
8.9 ± 0.3
Diabetic (treated)
PSCE (750 mg/kg)
10.1 ± 0.2
10.0 ± 0.3
9.6 ± 0.2
9.4 ± 0.2
Body weight (g)
Normal (control)
Distilled water
299.3 ± 9.9
327.3 ± 9.5
364.8 ± 4.1
403.3 ± 6.7
Diabetic (control)
Distilled water
279.3 ± 5.4
270.5 ± 3.1
258.3 ± 7.4
245.5 ± 6.0
Diabetic (treated)
Metformin (150 mg/kg)
282.3 ± 2.5
295.8 ± 2.9
308.3 ± 2.2
318.5 ± 1.3
Diabetic (treated)
PSCE (750 mg/kg)
275.8 ± 4.6
269.5 ± 4.7
264.5 ± 4.7
256.3 ± 2.1
Urine sugar (g/L)
Normal (control)
Distilled water
0
0
0
0
Diabetic (control)
Distilled water
+2
+2
+2
+2
Diabetic (treated)
Metformin (150 mg/kg)
+2
+1
0
0
Diabetic (treated)
PSCE (750 mg/kg)
+2
+2
+1
+1
as compared to diabetic control group (distilled water). as compared to diabetic treated group (metformin 150 mg/kg). as compared to pretreatment level (0 days). as compared to 7 days. as compared to 14 days. PSCE, Pleurotus sajor-caju aqueous extract.
