Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats
Table 3
Antidiabetic effects of oral administration of PSC aqueous extract on lipid profiles, liver function profiles, kidney function profiles, and HbA1c in mild diabetic rats (mean ± SD).
Experimental animals
Treatment
21 days Posttreatment level
Total cholesterol (mmol/L)
Normal (control)
Distilled water
1.5 ± 0.0
Diabetic (control)
Distilled water
1.9 ± 0.2
Diabetic (treated)
Metformin (150 mg/kg)
1.7 ± 0.1
Diabetic (treated)
PSCE (750 mg/kg)
1.8 ± 0.1
HDL cholesterol (mmol/L)
Normal (control)
Distilled water
1.2 ± 0.1
Diabetic (control)
Distilled water
1.5 ± 0.1
Diabetic (treated)
Metformin (150 mg/kg)
1.4 ± 0.1
Diabetic (treated)
PSCE (750 mg/kg)
1.4 ± 0.2
LDL cholesterol (mmol/L)
Normal (control)
Distilled water
0.2 ± 0.1
Diabetic (control)
Distilled water
0.4 ± 0.1
Diabetic (treated)
Metformin (150 mg/kg)
0.2 ± 0.1
Diabetic (treated)
PSCE (750 mg/kg)
0.3 ± 0.0
Triglyceride (mmol/L)
Normal (control)
Distilled water
0.5 ± 0.2
Diabetic (control)
Distilled water
0.6 ± 0.2
Diabetic (treated)
Metformin (150 mg/kg)
0.5 ± 0.1
Diabetic (treated)
PSCE (750 mg/kg)
0.6 ± 0.1
Urea (mmol/L)
Normal (control)
Distilled water
7.0 ± 0.5
Diabetic (control)
Distilled water
8.1 ± 0.3
Diabetic (treated)
Metformin (150 mg/kg)
7.4 ± 0.5
Diabetic (treated)
PSCE (750 mg/kg)
8.1 ± 0.3
Creatinine (mol/L)
Normal (control)
Distilled water
51.8 ± 2.6
Diabetic (control)
Distilled water
61.6 ± 0.0
Diabetic (treated)
Metformin (150 mg/kg)
54.6 ± 2.3
Diabetic (treated)
PSCE (750 mg/kg)
58.3 ± 2.1
Uric acid (mol/L)
Normal (control)
Distilled water
188.3 ± 13.1
Diabetic (control)
Distilled water
192.2 ± 13.0
Diabetic (treated)
Metformin (150 mg/kg)
191.8 ± 10.4
Diabetic (treated)
PSCE (750 mg/kg)
190.7 ± 15.6
Albumin (g/L)
Normal (control)
Distilled water
25.1 ± 1.6
Diabetic (control)
Distilled water
22.4 ± 1.5
Diabetic (treated)
Metformin (150 mg/kg)
23.7 ± 1.6
Diabetic (treated)
PSCE (750 mg/kg)
22.1 ± 1.8
Globulin (g/L)
Normal (control)
Distilled water
38.7 ± 1.9
Diabetic (control)
Distilled water
34.0 ± 2.3
Diabetic (treated)
Metformin (150 mg/kg)
35.9 ± 2.5
Diabetic (treated)
PSCE (750 mg/kg)
35.1 ± 2.6
Total bilirubin (mol/L)
Normal (control)
Distilled water
1.7 ± 0.0
Diabetic (control)
Distilled water
3.1 ± 0.2
Diabetic (treated)
Metformin (150 mg/kg)
1.7 ± 0.0
Diabetic (treated)
PSCE (750 mg/kg)
2.7 ± 0.5
HbA1c (%)
Normal (control)
Distilled water
3.7 ± 0.1
Diabetic (control)
Distilled water
6.2 ± 0.3
Diabetic (treated)
Metformin (150 mg/kg)
3.9 ± 0.2
Diabetic (treated)
PSCE (750 mg/kg)
5.8 ± 0.5
as compared to diabetic control group (distilled water). PSCE, Pleurotus sajor-caju aqueous extract.
