Genomic and Histopathological Tissue Biomarkers That Predict Radiotherapy Response in Localised Prostate Cancer

Table 2

Predictive tissue biomarkers for radiotherapy response identified using genomic techniques.

Marker/signature	Function	Technique
DNA ploidy [52]	Genomic instability	Image analysis (Feulgen) and DNA/protein flow cytometry
Nuclear DNA content [53]	Genomic instability	Static DNA cytometry
c-myc [54]	Cell proliferation	Array CGH validated by FISH
PTEN [54]	Cell survival	Array CGH validated by FISH
E-cadherin [15]	Cell adhesion	PCR array, IHC validation
NKX3.1 [55]	Androgen related homeobox gene, DNA repair	Array CGH
NBN [56]	DNA damage response	Array CGH
StAR [57]	Androgen synthesis	Array CGH
HSD17B2 [57]	Androgen synthesis	Array CGH
Cell cycle progression score [58]	Cell cycle progression	RT-PCR (RNA expression)
CAN_RF [59]	Genomic and microenvironment heterogeneity	Array CGH, intraglandular hypoxia with piezoelectrode

FISH: fluorescent in situ hybridisation; CGH: comparative genomic hybridisation; RT-PCR: reverse transcription polymerase chain reaction.