CD8⁺ T-Cells Count in Acute Myocardial Infarction in HIV Disease in a Predominantly Male Cohort

Table 1

Acute myocardial infarction rates and risk and all-cause mortality rates by HIV status, CD8⁺ T-cell count, and CD4⁺ T-cell strata.

Regression model^a	Independent variable^b	(% of HIV+)^c	AMI rate (95% CI)^d	HR (95% CI)	P value	Mortality rates; (95% CI)^q
I	Per 100 CD8^+cells (HIV+ only)	18,289		1.03 (1.01–1.05)	0.006
II	HIV-uninfected	55,109	18.49 (16.95–20.17)	1.00	Ref	18.63 (18.10–19.17)
	HIV+ All CD4^+ strata	18,289
	CD8^+ < 667	5,987 (32.74)	26.08 (20.70–32.86)	1.45 (1.12–1.88)^e	0.005	63.17 (60.00–66.51)
	CD8^+ 667–1065	6,185 (33.82)	26.98 (21.81–33.37)	1.54 (1.21–1.96)^f	<0.001	38.54 (36.23–41.00)
	CD8^+ > 1065	6,117 (33.45)	32.20 (26.50–39.14)	1.82 (1.46–2.28)^g	<0.001	40.89 (38.49–43.45)
III	HIV-uninfected	55,109	18.49 (16.95–20.17)	1.00	Ref	18.63 (18.10–19.17)
	HIV+ CD4^+ ≥ 500	5,422
	CD8^+ < 667	1,097 (20.23)	24.00 (14.70–39.18)	1.30 (0.76–2.20)^h	0.339	28.08 (24.05–32.78)
	CD8^+ 667–1065	1,971 (36.35)	26.68 (18.76–37.93)	1.51 (1.03–2.21)^i	0.037	24.83 (21.89–28.17)
	CD8^+ > 1065	2,354 (43.42)	28.68 (20.96–39.26)	1.69 (1.21–2.36)^j	0.002	30.66 (27.57–34.10)
	HIV+ CD4^+ 200–499	6,730
	CD8^+ < 667	1,901 (28.25)	21.54 (14.32–32.42)	1.22 (0.80–1.87)^k	0.360	43.88 (39.72–48.48)
	CD8^+ 667–1065	2,447 (36.36)	26.08 (18.81–36.16)	1.47 (1.03–2.09)^l	0.034	37.68 (34.27–41.42)
	CD8^+ > 1065	2,382 (35.40)	37.38 (28.25–49.46)	2.08 (1.53–2.82)^m	<0.001	43.52 (39.74–47.67)
	HIV+ CD4^+ < 200	4,447
	CD8^+ < 667	2,389 (53.72)	32.16 (22.86–45.23)	1.82 (1.26–2.64)^n	0.001	107.13 (100.36–114.35)
	CD8^+ 667–1065	1,171 (26.33)	29.60 (18.65–46.97)	1.80 (1.10–2.94)^o	0.019	67.40 (60.56–75.02)
	CD8^+ > 1065	887 (19.94)	27.89 (16.19–48.02)	1.51 (0.85–2.67)^p	0.158	63.32 (55.81–71.85)

^aThe covariates included in the multivariable models (hazard ratios not shown) were age, gender, race, high blood pressure (controlled/uncontrolled), diabetes, triglyceride levels, high density lipoprotein levels, low density lipoprotein levels, body mass index, smoking history, hepatitis C virus infection, estimated glomerular filtration rate, statin use, hemoglobin concentration, cocaine and alcohol abuse, and/or dependence.
^bCD8⁺ and CD4⁺ T-cell counts were measured in cells/mm³.
^cWhile all 18,289 HIV-infected participants had baseline CD8⁺ T-cell count measurements, 1,690 of them lacked baseline CD4⁺ counts. Thus, these persons were excluded from analyses involving both CD4⁺ and CD8⁺ T-cell counts.
^dAMI rates were measured per 10,000 person years.
^{e versus f} value comparing these hazard ratios was <0.001.
^{e versus g} value comparing these hazard ratios was <0.001.
^{f versus g} value comparing these hazard ratios was <0.01.
^{h versus i} value comparing these hazard ratios was 0.026.
^{h versus j} value comparing these hazard ratios was <0.001.
^{i versus j} value comparing these hazard ratios was <0.001.
^{k versus l} value comparing these hazard ratios was 0.092.
^{k versus m} value comparing these hazard ratios was <0.001.
^{l versus m} value comparing these hazard ratios was <0.001.
^{n versus o} value comparing these hazard ratios was 0.002.
^{n versus p} value comparing these hazard ratios was <0.004.
^{o versus p} value comparing these hazard ratios was <0.066.
^qAll-cause mortality rates were measured per 10,000 person years.