|
Resection group | Upregulated (log FC) | Downregulated (log FC) | Function | Reference |
|
3–0 weeks | COL1A2 (0.84) | | Acts as a structural component of the ECM | [19] |
SPARC (0.78) | | Influences the synthesis of ECM | [20] |
TCF4 (0.33) | | Is highly expressed in connective tissue fibroblasts | [21] |
ERBB3 (0.26) | | Involved in regulating the response of fibroblasts | [22] |
TFPI2 (0.26) | | Is an ECM structural constituent | [23] |
TIMP (0.14) | | Play a key role in maintaining the balance between ECM deposition and degradation | [24] |
|
6–3 weeks | | SPARC (−0.7) | Influences the synthesis of ECM | [20] |
|
Sham group | | | | |
|
3–0 weeks | BMP1 (0.22) | | Involved in ECM formation | [25] |
|
6–0 weeks | GNG11 (0.35) | | Induces cellular senescence in normal human fibroblasts | [26] |
BMP1 (0.23) | | Involved in ECM formation | [25] |
|
6–3 weeks | STEAP1 (0.29) | | A cell surface antigen expressed at cell-cell junctions | [27] |
| ITGAV (−0.15) | Interacts with receptors in the ECM | [23] |
| DSP (−0.47) | Desmoplakin is a cell surface adhesion protein | [28] |
|
Control group | | | | |
|
3–0 weeks | STEAP 1 (0.48) | | A cell surface antigen expressed at cell-cell junctions | [27] |
|
6–0 weeks | STEAP1 (0.65) | | A cell surface antigen expressed at cell-cell junctions | [27] |
F11R (0.54) | | Encodes JAM-A, a transmembrane protein interacting with molecules in the ECM | [29] |
OCLN (0.4) | | Encodes occludin, a transmembrane protein interacting with molecules in the ECM | [29] |
TFPI2 (0.38) | | Is an ECM structural constituent | [23] |
TCF4 (0.28) | | Is highly expressed in connective tissue fibroblasts | [21] |
|
6–3 weeks | | MMP2 (−0.44) | Involved in the breakdown of ECM in liver repair reactions | [30] |
|