SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure

Figure 1

Cardiovascular function in Atp2a2 heterozygous mice. Ventricular and arterial pressures were measured in anesthetized adult FVB/N wild-type and Atp2a2^+/− mice under baseline conditions and upon -adrenergic stimulation using dobutamine. (a) Heart rate (HR); (b) mean arterial pressure (MAP); (c) left ventricular end-diastolic pressure (LVEDP); (d) maximal rate of left ventricular pressure development (+dP/dt Max); (e) rate of left ventricular pressure development at 40 mmHg (dP/dt40); and (f) maximal rate of decay of left ventricular developed pressure (−dP/dt Max). Values are means ± SE. = at least 5 for each genotype.

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