Research Article
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure
Figure 3
Effects of hypothyroidism on cardiovascular performance of Atp2a2 heterozygous mice. Adult wild-type and Atp2a2+/− (HET) mice were rendered hypothyroid and cardiovascular performance was assessed under both baseline conditions and after -adrenergic stimulation. (a) Heart rate (HR); (b) mean arterial pressure (MAP); (c) systolic left ventricular pressure (systolic LVP); (d) maximal rate of left ventricular pressure development (+dP/dt Max); (e) rate of left ventricular pressure development at 40 mmHg (dP/dt40); (f) maximal rate of decay of left ventricular developed pressure (−dP/dt Max). Values are means ± SE. = at least 4 for each genotype.
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