Molecular Analysis of AFP and HSA Interactions with PTEN Protein

Figure 6

The binding interface of AFP and PTEN in the docking model, showing the individual residue contacts at the binding interface: AFP domain III residue D529 has a salt-bridge interaction with PTEN C2 domain residue N290; AFP domain I residue M490 has a hydrogen bond with PTEN phosphatase domain R150; residue S135 has a hydrogen bond with PTEN phosphatase domain residue Y14; domain I residue K107 has a hydrogen bond with H47. The L105 and E106 of AFP contacted with PTEN K46.