Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Table 1

Clusters and families of miRNAs significantly altered by H₂O₂ in villous 3A trophoblasts.

	Count	Percent^b	value^c
Cluster^a
hsa-let-7e cluster	3	100	0.0418
hsa-let-106b cluster	3	100	0.0418
hsa-let-23b cluster	3	100	0.0418
Family^a
let-7 family	9	100
mir-15 family	4	100	0.0144
mir-17 family	6	75	0.0237
mir-181 family	4	100	0.0144
mir-29 family	3	100	0.0418
mir-329 family	3	100	0.0418
mir-368 family	3	100	0.0418
mir-99 family	3	100	0.0418

 ^aAnalysis of overexpressed miRNAs was performed by TAM (tool for annotations of miRNAs, version 2). Size of miRNA category was set as 1–100.
^bPercent of miRNA changed between treated and controls cells within the cluster or family.
^c indicates a significant number of miRNAs altered within a cluster/family.