Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts
Table 2
Functional pathways regulated by miRNAs altered by H2O2 in villous 3A trophoblasts.
Functiona
Count
Percentb
valuec
Angiogenesis
14
61
Apoptosis
22
56
Bone regeneration
17
61
Cell cycle related
29
50
Cell proliferation
16
62
Epithelial-mesenchymal transition
24
63
Folliculogenesis
7
100
Granulopoiesis
9
90
Hormones regulation
29
54
Human embryonic stem cell (hESC) regulation
36
51
Immune response
29
73
Inflammation
22
65
Adipocyte differentiation
16
64
Anticell proliferation
11
100
Brain development
12
63
Cell death
31
62
Cell division
11
73
Cell fate determination
12
55
Hematopoiesis
18
62
Lipid metabolism
11
58
miRNA tumor suppressors
24
65
Onco-miRNAs
19
61
āaAnalysis of altered miRNAs was performed by TAM (tool for annotations of miRNAs, version 2). Size of miRNA category was set as 1ā100. bPercent of miRNA changed between treated and controls cells within a pathway/function. c indicates a significant number of miRNAs altered within a pathway/function.