Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Table 2

Functional pathways regulated by miRNAs altered by H₂O₂ in villous 3A trophoblasts.

Function^a	Count	Percent^b	value^c
Angiogenesis	14	61
Apoptosis	22	56
Bone regeneration	17	61
Cell cycle related	29	50
Cell proliferation	16	62
Epithelial-mesenchymal transition	24	63
Folliculogenesis	7	100
Granulopoiesis	9	90
Hormones regulation	29	54
Human embryonic stem cell (hESC) regulation	36	51
Immune response	29	73
Inflammation	22	65
Adipocyte differentiation	16	64
Anticell proliferation	11	100
Brain development	12	63
Cell death	31	62
Cell division	11	73
Cell fate determination	12	55
Hematopoiesis	18	62
Lipid metabolism	11	58
miRNA tumor suppressors	24	65
Onco-miRNAs	19	61

 ^aAnalysis of altered miRNAs was performed by TAM (tool for annotations of miRNAs, version 2). Size of miRNA category was set as 1–100.
^bPercent of miRNA changed between treated and controls cells within a pathway/function.
^c indicates a significant number of miRNAs altered within a pathway/function.