Administration of 4-(<i>α</i>-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1<sup>G93A</sup> Rats: A Transgenic Model of Amyotrophic Lateral Sclerosis

<div>Cleaved-caspase3 activation and dendritic spine detection. Western blot analysis of spleen homogenates revealed that, although not significantly, cleaved-caspase3 levels are higher in untreated SOD1tg rats than in animals that received the GMG-ITC treatment (a). Moreover a complete loss of nerve processes was detected in untreated SOD1tg rats (b) while treatment with GMG-ITC protects SOD1tg rats neurons that appear morphologically intact and with long dendrites establishing normal synapses (c).</div>

BioMed Research International

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Figure 11

Figure 11: Administration of 4-(<i>α</i>-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1<sup>G93A</sup> Rats: A Transgenic Model of Amyotrophic Lateral Sclerosis 

Figure 11 | Administration of 4-(α-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1G93A Rats: A Transgenic Model of Amyotrophic Lateral Sclerosis 