Coagulation Parameters and Risk of Progressive Hemorrhagic Injury after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Table 4

Effect of coagulopathy on PHI after traumatic brain injury.

Data type	Coagulation tests	Number of studies	Population size	for test	Heterogeneity ()	MD/OR (95% CI)
Continuous	PLT	4	1003	0.06	0	−7.24 −14.77, 0.28
	PT	2	630	0.56	90	0.25 −0.60, 1.11
	PTT	4	1026	0.92	33	0.05 −0.85, 0.94
	D-dimer	2	850	0.31	99	34.48 −32.15, 101.11
	Fg	3	1044	<0.001	0	−0.26 −0.39, −0.13
	INR	2	398	0.10	96	0.50 −0.09, 1.08
Dichotomous	PLT	4	1267	<0.001	35	2.76 1.62, 4.70
	PT	5	1644	<0.001	70	2.69 1.55, 4.66
	PTT	4	1289	0.15	70	2.39 0.72, 7.95
	D-dimer	3	1160	<0.001	63	16.50 4.94, 55.04
	Fg	3	1145	<0.001	0	3.44 2.37, 4.99
	INR	2	512	<0.001	0	3.70 1.11–6.29

APTT: activated partial thromboplastin time; Fg: fibrinogen/fibrin; INR: international normalized ratio; PHI: progressive hemorrhagic injury; PLT: platelet counts; PT: prothrombin time; CI: confidence interval; MD: mean difference; OR: odds ratio.