Temporal Changes of Microarchitectural and Mechanical Parameters of Cancellous Bone in the Osteoporotic Rabbit

Figure 6

Nanoindentation results of ((a), (b)) vertebral and ((c), (d)) femoral condylar cancellous bone specimens. Asterisks showed the statistically significant difference between OP group and sham group at the same time point. Four weeks onwards the values of (a) elastic modulus and (b) hardness of lumbar vertebrae in the OP group decreased significantly. Similar results of (c) elastic modulus and (d) hardness also appeared in femoral condyles. Transverse lines with asterisks above showed the differences in OP group among different time points. .

(a)

(b)

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(d)