Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 1

List of SNPs predicted by SIFT as damaging.

SNP	Position	Amino acid change	Prediction	Score	Median
rs145581875	50	N50S	Damaging	0.02	2.81
rs114166108	62	P62S	Damaging	0.02	2.81
rs182539049	184	L184S	Damaging	0.01	2.81
rs146781980	195	V195I	Damaging	0.02	2.81
rs145415894	276	A276V	Damaging	0.01	2.81
rs142939718	361	L361P	Damaging	0.02	2.78
rs145787003	406	S406F	Damaging	0.01	2.81
rs190359946	483	H483Q	Damaging	0.02	2.91
rs35896902	592	R592H	Damaging	0.01	3.1
rs143374873	727	C727Y	Damaging (low confidence)	0.03	3.63
rs150721457	673	I673T	Damaging	0.05	3.12