Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 2

List of SNPs that were predicted by PolyPhen-2 server as significantly damaging.

rsIDs	Amino acid position	Mutation	PSIC score	Effect
rs192719507	44	L44F	1	Probably damaging
rs151296858	59	G59S	1	Probably damaging
rs114166108	62	P62S	0.997	Probably damaging
rs113469614	65	N65K	0.989	Probably damaging
rs141809307	94	T94T	1	Probably damaging
rs56250729	97	I97L	0.997	Probably damaging
rs138740835	98	L98F	0.539	Possibly damaging
rs115634589	101	I101T	0.999	Probably damaging
rs182539049	184	L184S	0.992	Probably damaging
rs146781980	195	V195I	0.98	Probably damaging
rs138685180	224	L224P	0.999	Probably damaging
rs143565946	258	L258H	0.999	Probably damaging
rs145415894	276	A276V	1	Probably damaging
rs140715742	285	L285M	0.995	Probably damaging
rs35553278	289	A289T	0.591	Possibly damaging
rs151056294	318	K318T	0.651	Probably damaging
rs148464936	355	R355C	1	Probably damaging
rs142939718	361	L361P	1	Probably damaging
rs145787003	406	S406F	0.976	Probably damaging
rs486907	462	R462Q	0.998	Probably damaging
rs190359946	483	H483Q	1	Probably damaging
rs148411578	528	V528I	0.982	Probably damaging
rs193195484	532	V532I	0.999	Probably damaging
rs35896902	592	R592H	1	Probably damaging
rs147890567	595	T595M	1	Probably damaging
rs142133260	601	N601S	1	Probably damaging
rs150721457	673	I673T	1	Probably damaging

PSIC = position-specific independent count score.
[Damaging rsID predicted by both SIFT and PolyPhen-2 server are shown in bold letters].