Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 3

List of SNPs predicted to be disease related by 7 SNP analyzer algorithms. (T = tolerated, as predicted by SIFT.)

rsIDs	Mutation	PolyPhen-2 score	SIFT score	nsSNPs	PhD-SNP	PANTHER	SNPs&GO	P-Mut
rs151296858	G59S	1	T	Disease	Disease	Disease	Disease	—
rs114166108	P62S	0.997	0.02	Disease	Disease	Disease	Neutral	—
rs182539049	L184S	0.992	0.01	Disease	Disease	Disease	Neutral	—
rs138685180	L224P	0.999	T	Disease	Disease	Disease	Disease	Pathological
rs145415894	A276V	1	0.01	Disease	Disease	—	Neutral	Pathological
rs142939718	L361P	1	0.02	Disease	Disease	Disease	Disease	Pathological
rs35896902	R592H	1	0.01	Disease	Disease	Disease	Disease	Pathological
rs147890567	T595M	1	T	Disease	Disease	Disease	Neutral	Pathological
rs150721457	I673T	1	0.05	Disease	—	—	Disease	—