Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 4

Conservation profile of amino acids in RNASEL that coincide in location with high-risk nsSNPs.

rsIDs	Residue pos.	Residue	CS	Color	Buried or exposed	Function
rs151296858	59	G	−0.834	8	e	f
rs114166108	62	P	−0.99	9	e	f
rs182539049	184	L	−0.296	6	b
rs138685180	224	L	−0.146	6	b
rs145415894	276	A	−1.202	9	b	s
rs142939718	361	L	−1.16	9	b	s
rs35896902	592	R	−0.915	8	e	f
rs147890567	595	T	−0.345	6	b
rs150721457	673	I	−0.552	7	b

CS: conservation score (1–4 = variable, 5 = average, and 6–9 = conserved); (f): predicted functional site; (s): predicted structural site.