Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 6

RMSD () values and total free energy after energy minimization of the wild type and mutated protein models. RMSD calculated by Tm-Align and energy minimization was performed by YASARA force field.

Mutated models	Energy after minimization (kj/mol)	RMSD ()
Wild Type	−436437.8
R592H	−393543.3	2.59
P361	−396456.0	1.11
G59S	−399615.0	1.19
P62S	−405223.0	1.14
A276V	−431021.9	1.94
L184S	−403094.0	1.74
L224P	−402604.0	1.57
T595M	−422287.5	1.45
I673T	−403967.2	1.48