Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL

Table 7

I-mutant predictions for selected nsSNPs.

Mutation	Sign of DDG	DDG value prediction kcal/mol	RI	RSA
G59S	Decrease	−1.36	5	3.8
P62S	Decrease	−2.15	8	0.7
L184S	Decrease	−2.24	5	0.0
L224P	Decrease	−2.13	9	15.8
A276V	Increase	0.66	3	0.9
L361P	Decrease	−1.59	8	0.0
R592H	Decrease	−0.99	9	6.6
T595M	Decrease	−0.54	7	2.2
I673T	Decrease	−2.46	9	9.2

DDG: free energy change value in Kcal/mol (>0 increase, <0 decrease, >0.5 large increase, and <2.5 large decrease); sign of DDG: the direction of the change (increase or decrease); the reliability index (RI) from 0 to 9 is shown in parentheses, where 0 is the lowest RI and 9 is the highest; RSA: relative surface accessibility.