Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model
Table 1
Iron status in liver, glycemic and lipids profile, oxidant/antioxidant status in liver of rats offered a standard diet (S) and rats that received injections of iron dextran (SI).
S group
SI group
values
Liver iron µmol/100 mg tissue
0.02 ± 0.01
0.18 ± 0.05*
<0.0001
Cholesterol mmol/L of serum
1.26 ± 0.27
1.77 ± 0.33*
<0.05
HDL cholesterol mmol/L of serum
0.83 ± 0.17
0.93 ± 0.17
>0.05
Other fraction cholesterol mmol/L of serum
0.42 ± 0.28
0.84 ± 0.37*
<0.05
Triacylglycerol mmol/L of serum
1.15 ± 0.22
2.06 ± 0.59*
<0.01
Glucose mmol/L of serum
6.24 ± 0.96
7.34 ± 0.46*
<0.05
ALT (U/mL of serum)
23.72 ± 4.34
25.68 ± 7.32
>0.05
AST (U/mL of serum)
55.26 ± 4.26
56.92 ± 3.61
>0.05
Liver carbonyl protein (U/mg of protein)
2.95 ± 0.5
6.83 ± 1.86*
<0.0001
Liver TBARS (U/mg of protein)
1.47 ± 0.23
3.21 ± 0.38*
<0.0001
HDL, high-density lipoprotein; Values are shown as the mean ± standard deviation (). Data were analyzed by -test. Statistical differences are shown by *.
